Every now and then, a supplement comes along that defies the odds. In other words, it actually works the way its advertisers claim, and at the dosages recommended on the bottle. This is far from the norm though. The only clear-cut, non-steroidal anabolic agent and ergogenic aid to come out of the 90’s was Creatine.
5a-Hydroxy Laxogenin was discovered in 1996 and was shown to have an anabolic/androgenic ratio similar to the best anabolics, but without the side effects of liver toxicity or testing positive for steroidal therapy. Athletes claim to have seen strength increases in 3-5 days, and muscle mass increases in 3-4 weeks. Laboratory tests showed that protein synthesis increased by over 200%, the key to lean muscle growth and accelerated repair. In testing, 5a-Hydroxy Laxogenin has balanced cortisol response, which is the major cornerstone to healthy recovery and reduction of muscle wasting.
"The best (published) study can be found in the journal Phytochemistry, 1971, vol. 10, pp 1339-1346. Again in 1989, same journal vol. 28, no. 9 pp 2509-2511 (laxogenin acetate). There is reference going back to 1965 in Chem. Pharm. Bull. 13(5), pp. 545-550 (laxogenin).
It was Dr. Syrov's paper of 1976 though, appearing in Farmakol, Toksikol that really caused Hi-Tech researchers to begin looking into making this compound in 1994. The paper is entitled, "An Experimental Study on the Anabolic Activities of 6-keto Derivatives of some natural sapogenins". It details the 4 sapogenins (referred to as compounds 1-4 in the Soviet Union) and gives source material, results of the classic steroid model and mentions. 5a-Hydroxy Laxogenin appears to be Compound 2, the most desirable of these steroidal saponins.
A double-blind study of laxogenin and 5α-Hydroxy Laxogenin on athletic performance is shown below. One hundred healthy male bodybuilders volunteered for the 4-week double-blind study during an intensive training period. The subjects were randomly divided into three groups and assigned to receive 5α-Hydroxy Laxogenin, laxogenin and placebo (isomaltulose) everyday, respectively. The daily training schedule included barbell bench press, barbell bicep curls, seated leg press and seated leg press at 65% of the maximum exercise. Meanwhile, upper arm circumference, bust and thigh circumference were measured weekly. During the period, nobody was allowed to try a new supplement or drug. Daily food was not changed suddenly, and protein intake remained constant.
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